St. Vincent's Guest House (now Hotel Saint Vincent) is rumored to be haunted by the spirits of children who died at the original Saint Vincent's Infant Asylum, with guests and paranormal investigators reporting sightings of children's ghosts, unexplained sounds like children's feet and laughter, and objects moving. The building, founded in 1861 by philanthropist Margaret Haughery, originally served as a refuge for thousands of orphans and is now a historic hotel, contributing to its enduring spooky reputation and the basis for paranormal tours. The building was established in 1861 as the Saint Vincent's Infant Asylum by Margaret Haughery, a prominent figure in New Orleans known as "Our Margaret" for her community work and philanthropy. The asylum provided refuge for thousands of children, and its long history as a sanctuary for the vulnerable has contributed to its reputation as a haunted site. Many stories focus on the spirits of children who died at the original asylum, with guests claiming to have seen their apparitions. Visitors and guests have reported hearing the sounds of children's feet running and laughing, particularly in the early morning. There are claims of objects moving on their own, and some guests have experienced their beds shaking at night. Some accounts mention the ghost of a nun seen lurking in the outdoor hallways, as well as a message of "Help me" seen scrawled in the old lift.