Stories of hauntings at the Jemison-Van de Graaff Mansion in Tuscaloosa often center on the figure of a sad or forlorn woman seen gazing from a third-story window. While details vary among accounts, the sightings and other paranormal activity have been enough to include the mansion on local ghost tours, alongside other famously haunted sites in the city. The most prominent ghostly account involves a female apparition who is frequently spotted in an upstairs window of the Italianate villa. The spectral woman is often described as appearing melancholic, suggesting a backstory of tragedy connected to the home, though the specific details of her history are not widely publicized. Local ghost tour narratives suggest that there have been reports of other unexplainable events in the mansion, adding to its eerie reputation. The mansion's history and reputation have cemented its place on various "Haunted Tuscaloosa" tours.